{"id":17683,"date":"2021-01-04T15:51:17","date_gmt":"2021-01-04T13:51:17","guid":{"rendered":"http:\/\/cit.itim-cj.ro\/?page_id=17683"},"modified":"2021-10-01T08:00:14","modified_gmt":"2021-10-01T05:00:14","slug":"poveste-de-succes-raport-final-contract-subsidiar-parapharm","status":"publish","type":"page","link":"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-parapharm\/","title":{"rendered":"Poveste de succes &#8211; Raport final Contract subsidiar Parapharm"},"content":{"rendered":"<div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div  class=\"wpb_widgetised_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"widget widget_nav_menu\"><h5>Poveste de succes<\/h5><div class=\"menu-lista_succes-container\"><ul id=\"menu-lista_succes\" class=\"menu\"><li id=\"menu-item-17921\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17921\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-teracrystal\/\">Contract subsidiar TeraCrystal<\/a><\/li>\n<li id=\"menu-item-17687\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17687\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-etera-prod\/\">Contract subsidiar Etera Prod<\/a><\/li>\n<li id=\"menu-item-17686\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17686\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-parapharm\/\">Contract subsidiar Parapharm<\/a><\/li>\n<li id=\"menu-item-17819\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17819\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-icpe-bistrita\/\">Contract subsidiar ICPE Bistri\u021ba<\/a><\/li>\n<li id=\"menu-item-17853\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17853\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-agro-cosm-fan\/\">Contract subsidiar Agro Cosm Fan 1<\/a><\/li>\n<li id=\"menu-item-17880\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-17880\"><a href=\"http:\/\/cit.itim-cj.ro\/en\/poveste-de-succes-raport-final-contract-subsidiar-agro-cosm-fan-2\/\">Contract subsidiar Agro Cosm Fan 2<\/a><\/li>\n<\/ul><\/div><\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3>Curcumin\u0103 mai solubil\u0103<\/h3>\n\n\t\t<\/div> \n\t<\/div> <div class=\"separator  transparent\" style=\"\"><\/div>\n\n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper vc_box_shadow  vc_box_border_grey\"><img width=\"1000\" height=\"439\" src=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm.jpg\" class=\"vc_single_image-img attachment-full\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm.jpg 1000w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm-300x132.jpg 300w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm-768x337.jpg 768w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm-16x7.jpg 16w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parafarm-700x307.jpg 700w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p align=\"justify\">Datorit\u0103 tendin\u021bei la nivel global de limitare a utiliz\u0103rii ingredientelor artificiale \u00een alimente, medicamente \u0219i produse cosmetice, \u00een ultimele decenii acestea sunt \u00eenlocuite cu ingrediente de provenien\u021b\u0103 natural\u0103. \u00cen plus, s-a dezvoltat o pia\u021b\u0103 extrem de important\u0103 pentru cre\u0219terea calit\u0103\u021bii vie\u021bii, cea a suplimentelor alimentare, care au la baza substan\u021be de provenien\u021b\u0103 natural\u0103.<\/p>\n<p align=\"justify\">\u00centre miile de plante ce con\u021bin substan\u021be cu efect terapeutic cunoscut din Antichitate se num\u0103r\u0103 turmericul (Curcuma longa), originar din India, folosit de multe secole \u00een calitate de condiment, dar \u0219i \u00een scop medicinal.<\/p>\n<p align=\"justify\">Curcumina, principalul component al extractului din r\u0103d\u0103cina de turmeric, este studiat\u0103 pentru activitatea sa farmacologic\u0103, \u00een leg\u0103tur\u0103 cu poten\u021bialele ac\u021biuni antioxidante, antibacteriene, antifungice, antivirale \u015fi antiinflamatorii. Recent a fost studiat\u0103 eficien\u021ba curcuminei \u00een ameliorarea anumitor tipuri de cancer: pancreatic, gastric, cervical \u015fi colorectal. Datorita poten\u021bialului farmacologic pe care \u00eel prezint\u0103 se prognozeaz\u0103 o cre\u0219tere dinamic\u0103 a utiliz\u0103rii curcuminei de la o pia\u021b\u0103 global\u0103 de 56.23 de milioane USD, c\u00e2t era \u00een 2017, la 115 milioane USD estimat \u00een 2025.<\/p>\n<p align=\"justify\">Eficacitatea terapeutic\u0103 a compu\u0219ilor bioactivi, at\u00e2t de sintez\u0103 c\u00e2t \u0219i de provenien\u021b\u0103 natural\u0103 este de foarte multe ori limitat\u0103 de a\u0219a-numita biodisponibilitate \u2212 procentul din cantitatea de substan\u0163\u0103 ingerat\u0103 care este asimilat\u0103 de c\u0103tre organism.<\/p>\n<p align=\"justify\">Sunt numero\u015fi factori care influen\u0163eaz\u0103 \u00een mod direct biodisponibilitatea, printre care o importan\u021b\u0103 deosebit\u0103 o au solubilitatea \u0219i permeabilitatea.<\/p>\n<p align=\"justify\">Curcumina, de\u0219i este acceptat\u0103 de organismul uman \u00een doze mari de p\u00e2n\u0103 la 12 g\/zi, manifest\u0103 o ac\u021biune terapeutic\u0103 mult redus\u0103 din cauza solubilit\u0103\u0163ii foarte sc\u0103zute (11 ng\/ml \u00een solu\u021bie apoas\u0103 cu pH=5) \u015fi a instabilit\u0103\u0163ii sale chimice.<\/p>\n<p align=\"justify\">Eforturile de cercetare \u00een asemenea situa\u021bii sunt \u00eendreptate \u00eenspre identificarea unor forme solide noi ale compusului bioactiv care s\u0103 prezinte solubilitate m\u0103rit\u0103, dar \u0219i alte propriet\u0103\u021bi fizico-chimice \u00eembun\u0103t\u0103\u021bite, \u00een scopul ob\u021binerii de produse cu calit\u0103\u021bi superioare.<\/p>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div align=\"justify\">\n<p><img loading=\"lazy\" class=\"alignright wp-image-17722\" src=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima-300x200.jpg\" alt=\"\" width=\"350\" height=\"233\" srcset=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima-300x200.jpg 300w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima-768x511.jpg 768w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima-16x12.jpg 16w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima-700x466.jpg 700w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/materie-prima.jpg 1000w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><\/p>\n<p><strong>Turmericul<\/strong> este o plant\u0103 medicinal\u0103 a c\u0103rei larg\u0103 utilizare dateaz\u0103 \u00een cultura Vedic\u0103 din India (aproximativ 4000 ani), iar medicina modern\u0103 \u00eencearc\u0103 s\u0103 reconstituie \u00eentrebuin\u021b\u0103rile acestuia.<\/p>\n<p>India produce aproape toat\u0103 cantitatea de turmeric din lume \u0219i consum\u0103 80% din aceasta. Datorit\u0103 calit\u0103\u021bii sale excep\u021bionale \u0219i con\u021binutului ridicat de curcumin\u0103, turmericul indian este considerat cel mai bun. Erode, un ora\u0219 din statul Tamil Nadu din sudul Indiei, este cel mai mare produc\u0103tor \u0219i cel mai important centru comercial pentru turmeric, fiind cunoscut \u0219i sub numele de \u201eOra\u0219ul galben\u201d, \u201eOra\u0219ul turmeric\u201d sau \u201eOra\u0219ul textil\u201d.<\/p>\n<p>At\u00e2t \u00een medicina ayurvedic\u0103, c\u00e2t \u0219i \u00een cea tradi\u021bional\u0103 chinez\u0103 turmericul se utilizeaz\u0103 \u00een profilaxia \u0219i tratamentul a nenum\u0103rate boli, inclusiv consolidarea energiei globale a organismului.<\/p>\n<p>Turmericul este folosit de asemenea ca aliment \u0219i ingredient cosmetic. Culoarea galben\u0103 deosebit\u0103 a curry-ului se datoreaz\u0103 acestuia. Consumul de turmeric \u00een \u021b\u0103rile asiatice este cuprins \u00eentre 200-1000 mg\/zi\/ persoan\u0103.<\/p>\n<p>Principalele componente extrase din turmeric sunt un ulei volatil cu con\u021binut de turmeron \u0219i agen\u021bi coloran\u021bi numi\u021bi curcuminoide. Dintre acestea, un interes major se acord\u0103 curcuminei, prezent\u0103 \u00een propor\u021bie de 5-6% \u00een turmeric.<\/p>\n<p>Peste 100 de componente au fost izolate din turmeric. Componenta principal\u0103 a r\u0103d\u0103cinii este un ulei volatil care con\u021bine turmeron \u0219i al\u021bi agen\u021bi coloran\u021bi numi\u021bi curcuminoizi. <strong><br \/><\/strong><\/p>\n<\/div>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div align=\"justify\">\n<p>Forma solid\u0103 este un termen general care se refer\u0103 la noi tipuri de materiale, cristaline sau amorfe, cu impact asupra propriet\u0103\u021bilor structurale \u0219i fizico-chimice ale substan\u021belor chimice.<\/p>\n<p>Exist\u0103 preocup\u0103ri intense printre produc\u0103tori \u00een ceea ce prive\u0219te \u00eembun\u0103t\u0103\u021birea solubilit\u0103\u021bii, vitezei de dizolvare, stabilit\u0103\u021bii, higroscopicit\u0103\u021bii \u0219i biodisponibilit\u0103\u021bii substan\u021belor bioactive prin ob\u021binerea de noi forme solide (polimorfi, solva\u021bi, cocristale, s\u0103ruri, complec\u0219i de incluziune) ale acestora.<\/p>\n<p>Pentru screening-ul de forme solide noi, \u00een Laboratorul de Cristalizare \u0219i Polimorfism sunt implementate metode moderne \u00een regim high-throughput, cum ar fi cristalizarea paralel\u0103, m\u0103cinarea umed\u0103 sau uscat\u0103, evaporarea lent\u0103, cristalizarea \u00een suspensie, difuzia \u00een faz\u0103 lichid\u0103 sau de vapori \u0219i includerea \u00een molecule gazd\u0103.<\/p>\n<\/div>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element  vc_custom_1610610284506\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div align=\"justify\">\n<p>Pe pia\u021ba suplimentelor alimentare sunt prezente un num\u0103r mare de produse cu con\u021binut de curcumin\u0103, \u00eens\u0103 pu\u021bine dintre acestea au la baz\u0103 forme cu solubilitate acceptabil\u0103. \u00cen acest context s-a derulat contractul de cercetare dintre INCDTIM \u0219i SC Parapharm SRL, finan\u021bat par\u021bial din Fonduri Structurale prin intermediul proiectului TTC-ITIM.<\/p>\n<h4>Obiectivul principal al contractului l-a constituit ob\u021binerea unei forme noi a curcuminei, cu biodisponibilitate m\u0103rit\u0103, \u0219i dezvoltarea procesului de sintez\u0103 la scal\u0103 mare (grame) a acesteia.<br \/>Implementarea contractului a fost realizat\u0103 de c\u0103tre o echip\u0103 multidisciplinar\u0103 alc\u0103tuit\u0103 din opt cercet\u0103tori: chimi\u0219ti, fizicieni \u0219i biologi.<\/h4>\n<\/div>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div align=\"justify\">\n<p>Pentru \u00eendeplinirea obiectivului s-au testat numeroase metode de \u00eembun\u0103t\u0103\u021bire a solubilit\u0103\u021bii: prepararea de forme solide noi (polimorfi, cocristale), prepararea de dispersii solide, folosirea de transportori sau tehnici de formulare diferite. Fiecare sistem nou ob\u021binut a fost apoi caracterizat structural \u0219i fizico-chimic.<\/p>\n<p>\u00cen final, echipa de cercet\u0103tori de la INCDTIM a reu\u0219it s\u0103 identifice \u0219i s\u0103 caracterizeze o form\u0103 solid\u0103 nou\u0103, cu solubilitate superioar\u0103, a curcuminei.<\/p>\n<p>Solubilitatea produsului nostru, ~ 60 \u00b5g\/ml, este de aproape patru ori mai mare dec\u00e2t a curcuminei \u00een produsul indicat de c\u0103tre beneficiar ca fiind de referin\u021b\u0103 (Produs 1), \u0219i de zeci de ori mai mare dec\u00e2t a celorlalte produse pe baz\u0103 de curcumin\u0103 testate (Produs 2 \u0219i 3).<\/p>\n<p><img loading=\"lazy\" class=\"alignnone size-large wp-image-17720\" src=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-1024x351.jpg\" alt=\"\" width=\"1024\" height=\"351\" srcset=\"http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-1024x351.jpg 1024w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-300x103.jpg 300w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-768x264.jpg 768w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-1536x527.jpg 1536w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-2048x703.jpg 2048w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-16x5.jpg 16w, http:\/\/cit.itim-cj.ro\/wp-content\/uploads\/2021\/01\/parapharma2-01-700x240.jpg 700w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p>Rezultatul ob\u021binut a fost transferat c\u0103tre compania Parapharm, \u00een acest moment firma de\u021bin\u00e2nd drepturile de proprietate intelectual\u0103. \u00cen urma unei analize cost\/beneficiu SC Parapharm SRL va decide \u00een final dac\u0103 \u00eel va include \u00een portofoliul s\u0103u de produse.<\/p>\n<\/div>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-3\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-9\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div align=\"justify\">\n<p><em><strong>Contractul subsidiar Nr. 259\/16.02.2018 \u00eentre INCDTIM Cluj \u0219i SC Parapharm SRL a fost derulat pe parcursul a 18 luni. Din valoarea total\u0103 de 300.000 de lei a contractului, 60.000 de lei reprezint\u0103 contribu\u021bia privat\u0103 a companiei, iar restul de 240.000 de lei sunt ajutor de stat, acordat prin intermediul proiectului \u201cCre\u015fterea capacit\u0103\u0163ii de transfer tehnologic \u015fi de cuno\u015ftin\u0163e a INCDTIM Cluj \u00een domeniul bioeconomiei TTC-ITIM\u201d (Cod SMIS 105533), derulat \u00een cadrul Programului Opera\u021bional Competitivitate 2014-2020.<\/strong><\/em><\/p>\n<p><a href=\"\/wp-content\/uploads\/2021\/10\/Poveste-de-succes-Parapharm.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Descarc\u0103 Povestea de succes Parapharm \u00een format pdf.<\/a><\/p>\n<\/div>\n\n\t\t<\/div> \n\t<\/div> <\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"Poveste de succesContract subsidiar TeraCrystal Contract subsidiar Etera Prod Contract subsidiar Parapharm Contract subsidiar ICPE Bistri\u021ba Contract subsidiar Agro Cosm Fan 1 Contract subsidiar Agro Cosm Fan 2 Curcumin\u0103 mai solubil\u0103 Datorit\u0103 tendin\u021bei la nivel global de limitare a utiliz\u0103rii ingredientelor artificiale \u00een alimente, medicamente...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/pages\/17683"}],"collection":[{"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/comments?post=17683"}],"version-history":[{"count":16,"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/pages\/17683\/revisions"}],"predecessor-version":[{"id":17948,"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/pages\/17683\/revisions\/17948"}],"wp:attachment":[{"href":"http:\/\/cit.itim-cj.ro\/en\/wp-json\/wp\/v2\/media?parent=17683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}